OTR Therapeutics: Catalyzing early innovation into global impactful therapies

At OTR, we champion scientific excellence and collaboration. Our culture thrives on open dialogue and diverse perspectives, uniting mission-driven colleagues around one goal: exploring innovative and efficient ways in delivering therapies that change lives.

Join us to redefine what's possible in serving patients.

We value team members who combine intellectual curiosity with practical problem-solving—professionals who challenge assumptions while remaining grounded in evidence and deliver impactful results.

Email your resume to careers@otr-tx.com

Find opportunities at OTR

Associate Director to Senior Director, CADD

Shanghai

【Key Responsibilities】

Design and implement computational strategies to support hit identification, hit-to-lead, and lead optimization stages of small molecule drug discovery. Collaborate closely with medicinal chemists, biologists, DMPK and AI/ML scientists to integrate computational insights into SAR design. Apply a range of modeling techniques including structure-based drug design (SBDD), ligand-based modeling, molecular dynamics, and cheminformatics. Analyze SAR data and generate predictive models to guide design hypotheses. Contribute to target assessment and binding site evaluation for new project opportunities. Maintain and develop internal modeling tools and workflows, and evaluate emerging computational technologies. Communicate results and recommendations clearly in team meetings and project reports.

【Qualifications】

Ph.D. in computational chemistry, medicinal chemistry, structural biology, or a related discipline, with >5 years of industry experience in CADD. Strong expertise in molecular modeling tools (e.g., Schrodinger Suite, MOE, AlphaFold2, etc.) and scripting languages (e.g., Python, R). Experience in applying SBDD and ligand-based approaches in real-world drug discovery projects. Familiarity with machine learning applications in drug design is a plus. Excellent interpersonal and communication skills, and a collaborative mindset.

AI Application Engineer

Shanghai

【Key Responsibilities】

1. Build and Maintain AI-Powered Biomedical Knowledge Systems Develop and maintain biomedical knowledge graphs by integrating data from literature, patents, chemical, and biological databases Apply advanced OCR, and LLM models to automate the extraction, structuring, and summarization of drug discovery and development data Design Retrieval-Augmented Generation (RAG) pipelines to support internal search and chatbot 2. Design AI Agents for Drug Discovery and Competitive Intelligence Develop intelligent agents to assist in literature mining, competitive landscape analysis, target-disease linkage, and experimental design optimization Construct intelligent compound and bioassay data management platforms to support medicinal chemistry and pharmacology teams Enable AI-based reasoning capabilities to assist internal stakeholders in hypothesis generation and validation 3. Drive Integration of AI in Drug R&D Workflows Collaborate closely with biology, chemistry, and clinical R&D teams to identify high-impact use cases and implement AI solutions Deliver AI prototypes and tools that improve R&D efficiency, quality, and innovation

【Qualifications】

Required: Master’s degree or above in Computer Science, Artificial Intelligence, Bioinformatics, Computational Biology, or a related field 2+ years of experience in AI/ML application development, preferably in the biomedical or pharmaceutical domain Strong programming skills in Python; proficient with ML/DL frameworks such as PyTorch or TensorFlow Practical experience with Retrieval-Augmented Generation (RAG), LLM-based architectures, or semantic search systems Preferred: Hands-on experience developing knowledge bases or knowledge graphs in the life sciences domain Familiarity with biomedical data standards, ontologies, and medical/bioinformatics databases Experience working with multi-modal data (text, image, structure) from public or proprietary drug discovery datasets Background in cheminformatics, computational chemistry, or related fields is a strong plus

Principal Scientist to Director, CMC Small Molecule

Shanghai

【Key Responsibilities】

Design and oversee critical CMC studies for external project evaluations, ensuring robust experimental planning and data interpretation. Manage and coordinate interactions with CROs, including study design, execution oversight, and results assessment to ensure material planning to meet timeline and quality requirement. Work cross-functionally with internal teams (medicinal chemistry, biology, DMPK, toxicology, regulatory affairs, clinical development) to support CMC activities from preclinical candidate (PCC) selection to Phase 1/2 clinical trials. Lead internal and external collaborations to ensure smooth progression of CMC activities, optimizing formulation development and manufacturing processes. Provide guidance on pre-formulation and regulatory CMC requirements to ensure compliance with industry and regulatory standards.

【Qualifications】

PhD in pharmaceutical science or related discipline. At least 3 years of industry experience in CMC development within a pharmaceutical or biotech company; candidates from relevant CRO backgrounds will also be considered. Strong expertise in small molecule drug development, formulation sciences, and regulatory CMC guidelines. Experience managing cross-functional collaborations and external CRO partnerships. Excellent communication, leadership, and project management skills. Ability to navigate and conduct preliminary bench experiment to solve preform issues.

Principal Scientist to Director, DMPK

Shanghai

【Key Responsibilities】

Design critical DMPK studies to evaluate external projects, guide CRO selection, manage external collaborations, and interpret experimental results. Collaborate effectively with senior scientific advisors/consultants to provide expert insights for strategic decision-making. Work closely with internal cross-functional teams, including chemistry, biology, DMPK, toxicology, CMC and regulatory colleagues, to optimize molecules from early discovery through IND enabling studies into Phase 1 clinical development. Provide strategic and scientific leadership to advance internal R&D programs efficiently and successfully.

【Qualifications】

PhD in Pharmacokinetics, Drug Metabolism, Pharmaceutical Sciences, or a closely related discipline. Minimum of 5 years of relevant industry experience in drug discovery and development, with extensive expertise in DMPK. Proven ability to independently design and manage pivotal DMPK studies, analyze complex data, and effectively communicate results. Excellent skills in collaboration, communication, and project management. Experience working with CROs and managing external partnerships.

Senior Manager to Director, IP

Shanghai

【Key Responsibilities】

Patent Portfolio Development & Management Strategize and execute global patent filings (including compound, salt, polymorph, formulation, combination, method-of-use, and synthesis patents) in alignment with R&D progress and corporate goals. Draft, file, and prosecute patent applications in China and internationally (PCT, US, EP, JP, etc.). Oversee the full patent lifecycle including Office Action responses, appeals, reexaminations, and maintenance fee management. Coordinate with external patent agents and international counsel to ensure efficient and high-quality IP prosecution. Freedom-to-Operate (FTO) & Risk Assessment Lead comprehensive FTO and patentability analyses for preclinical and clinical-stage assets. Assess infringement risks, propose mitigation strategies, and provide timely recommendations to R&D and BD teams. Monitor third-party IP landscape and competitive filings; identify white space for new filings or in-licensing opportunities. IP Due Diligence & Transaction Support Support BD activities by conducting IP due diligence and evaluating IP risks and opportunities in licensing, collaboration, and acquisition deals. Draft and negotiate IP-related clauses in contracts, including license agreements, MTAs, and joint development agreements. Collaborate with external partners to manage IP terms throughout the collaboration lifecycle. IP Strategy & Governance Design and implement IP strategies across therapeutic programs; ensure alignment with scientific, regulatory, and commercial objectives. Develop internal SOPs for IP management; lead internal training to enhance team awareness of IP practices and compliance. Support corporate IP audits, government reviews, and regulatory filings with respect to intellectual property. Internal Collaboration & Invention Mining Partner closely with scientists across medicinal chemistry, CMC, DMPK, and biology to identify patentable inventions. Guide scientists through invention disclosure processes and provide patent education as needed. Contribute to cross-functional strategic decisions by providing IP insights.

【Qualifications】

Advanced degree in Chemistry, Pharmaceutical Sciences, or a related field; PhD preferred. Qualification as a Patent Attorney or Agent in China (CNCIPA), US (USPTO), or Europe (EPO) is highly desirable. Strong background in small molecule patents with experience in FTO, prosecution, due diligence, and portfolio strategy. Excellent analytical, communication, and negotiation skills with cross-functional collaboration experience. Fluent in written and spoken English.

Principal Scientist to Executive Director, Medicinal Chemistry

Shanghai

【Key Responsibilities】

Design and oversee key medicinal chemistry strategies to evaluate external projects, ensuring optimal experimental design and data interpretation. Lead interactions with CROs, including study design, execution, oversight, and results assessment. Collaborate with senior scientific advisors/consultants to refine strategies and guide SAR design and decision-making. Work cross-functionally with internal teams (DMPK, biology, toxicology, CMC, patent and regulatory affairs) to optimize SAR from discovery through clinical candidate. Experienced with IND-enabling studies. Provide scientific and strategic leadership to advance internal R&D programs efficiently and effectively.

【Qualifications】

PhD in Medicinal Chemistry, Organic Chemistry, or a related discipline. At least 5 years of relevant industry experience in drug discovery and development, with extensive expertise in medicinal chemistry. Proven ability to design and manage complex medicinal chemistry programs, analyze structure-activity relationships (SAR), and guide lead optimization. Experience working with CROs and managing external collaborations. Strong collaboration, communication, and project management skills.

Principal Scientist, Biology

Shanghai

【Key Responsibilities】

Target nomination and validation for drug discovery project. Design and establishment of compound evaluation platform. Internal and external collaboration with cross-function team.

【Qualifications】

PhD in immunology, oncology, or related field with at least 2-5 years of industry experience. Deep knowledge in immunology and/or oncology. Experience in target search, evaluation, and nomination for innovative pipeline of immunology or oncology. Proficiency with enzymatic and binding assay (ADP-Glo/ELISA/HTRF/AlphaLISA), cellular reporter and immune cell differentiation assay, shRNA/CRISPR-based gene manipulation, standard immunology assays including multi-color flow cytometry, ELISpot, cytokine profiling (MSD/Luminex/ELISA). Proven ability in critical thinking, problem solving and working experience with cross-functionally team in a fast-paced environment. Experience with CRO management is a plus. Excellent organizational, written and oral communication skills, efficient time management.

Senior Scientist, Biology

Shanghai

【Key Responsibilities】

Assay development for drug discovery project. Data generation and analysis for compound evaluation. Laboratory set-up and management.

【Qualifications】

Master in immunology, oncology, or related field with 3-6 years of industry experience. Extensive expertise with enzymatic and binding assay (ADP-Glo/ELISA/HTRF/AlphaLISA), cellular reporter and immune cell differentiation assay, shRNA/CRISPR-based gene manipulation, standard immunology assays including multi-color flow cytometry, ELISpot, cytokine profiling (MSD/Luminex/ELISA). Strong data analysis capability, including experiment design, assay troubleshooting, data processing, interpretation, and presentation. Excellent organizational, written and oral communication skills, efficient time management.

Principal Scientist to Director, Toxicology

Shanghai

【Key Responsibilities】

Design and oversee key toxicology studies for external project evaluations, ensuring robust experimental design and data interpretation. Lead interactions with CROs, including study design, execution oversight, and results assessment and interpretation. Collaborate with senior scientific advisors/consultants to refine safety strategies and provide expert toxicology insights for decision-making. Work cross-functionally with internal teams (medicinal chemistry, DMPK, biology, CMC and regulatory affairs) to provide toxicology evaluation and insights from discovery through IND-enabling studies and Phase 1 clinical development. Provide scientific and strategic leadership in toxicology to support both internal R&D and external BD initiatives.

【Qualifications】

PhD in Toxicology, Pharmacology, or related disciplines. At least 5 years of relevant industry experience in preclinical toxicology and early clinical patient safety, with a strong understanding of regulatory and investigative toxicology principles. Proven ability to design and manage pivotal toxicology studies, analyze complex safety data, and interpret and effectively communicate results. Experience working with CROs and managing external collaborations. Strong collaboration, communication, and project management skills.

Alliance Manager / Senior Manager

Shanghai

【Key Responsibilities】

1.Cooperative Management and Communication Coordination • As the primary contact person for partner relationships, responsible for daily communication and relationship maintenance; organize and facilitate governance meetings such as JSC (Joint Steering Committee) and Working Groups, including agenda setting, material preparation, meeting minutes, and action item tracking. • Ensure correct understanding and consistent implementation of cooperation agreement terms (milestones, data sharing, decision rights, IP obligations, etc.) by both parties. 2.Project Execution and Cross-functional Collaboration • Work closely with internal functions including R&D, Clinical, CMC, QA, Regulatory Affairs, and Finance to ensure alignment between internal resources and external partnership strategies. • Lead the planning of deliverables timelines for collaborations, monitor progress, identify deviations, and drive corrective actions. • Stay vigilant regarding various compliance requirements specified in contracts, ensuring all collaboration-related activities such as data transfer are conducted legally and in compliance with regulations. 3. Risk Management and Problem Solving • Identify operational risks and legal/contractual risks during cooperative implementation, and develop solutions or escalation recommendations. • Collaborate with BD as needed to facilitate interpretation or revision of contract terms. 4. Business Support and Contract Execution • Support project transition from BD stage to post-deal integration. • Monitor and manage financial matters related to cooperation. • Assist in preparing periodic cooperation execution reports.

【Qualifications】

Bachelor's degree or above in medicine, pharmacy, biology, chemistry or related fields (preferably with master's or doctoral background). • 3-5 years of experience in biopharmaceutical industry, with specific experience in project management, BD/Ops, R&D or alliance management. • Familiar with drug development process from preclinical research → IND → early clinical development. • Prior experience in early-stage biopharma BD, technology transfer, or co-development/JV models, as well as experience in establishing alliance process systems is preferred. • Strong cross-functional coordination, project management and communication skills, able to manage partner expectations and guide consensus. • Proactive and stable working style, able to maintain momentum in high-pressure and ambiguous environments. • Excellent written and oral English skills.

Senior Project Manager to Associate Director, Clinical Project Management

Shanghai

【Key Responsibilities】

Oversight of clinical studies through collaboration with various CROs. Develop comprehensive project plans, timelines, budgets, and risk management strategies; monitor progress and implement corrective actions as needed. Coordinate and manage global clinical studies, with a strong emphasis on U.S.-China dual regulatory submissions (FDA and NMPA), ensuring alignment of study design, endpoints, and operational execution to meet both agencies’ expectations. Oversee vendor selection, contract negotiation, and performance management of external partners (e.g., CROs, central labs). Prepare and present project updates, milestones, and critical issues to senior management and governance committees. Contribute to regulatory submissions (IND, NDA, BLA, etc.) by providing clinical operations input and supporting documentation. Identify and engage with study sites (Investigators, study nurses, etc.) to ensure smooth trial execution and address site-related issues. Collaborate closely with internal teams to drive project success and facilitate cross-departmental meetings to resolve interdepartmental challenges and promote synergy. Establish and maintain a robust documentation management system for secure storage, timely updates, and easy access.

【Qualifications】

Master degree or above in Medicine, Pharmacy, Life Sciences, or a related scientific field. Minimum of 3–5 years of clinical trial project management experience in the pharmaceutical, biotechnology industry. Demonstrated experience in oncology or immunology clinical development, including hands-on management of Phase I trials (Phase II/III will be a plus). Proven track record of independently leading clinical projects from initiation (full cycle experience will be a plus). Essential experience in managing or supporting clinical trials in the U.S., including interaction with U.S.-based regulatory bodies, investigators, or CROs. Certain understanding of clinical development processes and regulatory requirements in both the U.S. (FDA) and China (NMPA), with direct involvement in dual-submission strategies. Fluent in English, with strong spoken and written communication skills – must be able to conduct meetings, write reports, and negotiate contracts in English.

Senior Manager to Director, Clinical Research Physician

Shanghai

【Key Responsibilities】

Trial Design and Protocol Development Collaborate with cross-functional teams to develop robust clinical trial protocols and study designs. Contribute to the development of clinical strategies, including study endpoints, randomization methods, sample size calculations, and statistical analysis plans. Prepare and review clinical study protocols, Investigator Brochures (IBs), Case Report Forms (CRFs), and informed consent forms (ICFs), ensuring alignment with ICH-GCP guidelines and regulatory requirements. Medical Monitoring Oversee study conduct, including site initiation, subject recruitment, and data collection to ensure adherence to protocols and ethical guidelines. Perform regular medical monitoring activities, including review of adverse events (AEs), serious adverse events (SAEs), and laboratory data to assess safety profiles. Collaborate with Principal Investigators (PIs) and study sites to resolve medical queries, manage protocol deviations, and escalate critical issues to leadership. Data Analysis and Report Preparation Collaborate with biostatisticians to review statistical analysis plans and interpret clinical data. Prepare comprehensive clinical study reports (CSRs), interim analyses, and regulatory submissions (e.g., IND/NDA documents). Contribute to the development of scientific presentations, manuscripts, and abstracts for publication or conference presentations. Key Opinion Leader (KOL) Engagement Establish and maintain relationships with academic experts and thought leaders in the therapeutic area. Facilitate scientific discussions, advisory boards, and expert consultations to gather insights and support study strategies. Provide medical education and training to internal/external stakeholders (e.g., CROs, study teams) on study protocols and disease-specific knowledge. Regulatory and Compliance Ensure all study activities comply with global regulatory guidelines (e.g., ICH-GCP, FDA/NMPA requirements). Participate in regulatory meetings and respond to agency queries during IND/NDA submissions. Maintain up-to-date knowledge of evolving regulatory landscapes and therapeutic guidelines.

【Qualifications】

Medical Doctorate (MD) or PhD with a strong background in clinical research. Minimum 3+ years of experience as a CRP in the biopharmaceutical industry. Proven track record in managing clinical trials from design to execution, with experience in global multi-regional studies preferred. Deep understanding of ICH-GCP, clinical trial methodologies, and regulatory submission processes. Strong analytical skills in interpreting clinical data and statistical outcomes. Excellent communication skills (verbal and written) to engage with diverse stakeholders (PIs, regulatory bodies, internal teams). Fluent in English (both verbal and written) to support global communication and document drafting. Ability to work in a dynamic, fast-paced environment and manage multiple projects simultaneously.

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Terms and Conditions ｜Privacy Policy

<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Introduction<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">OTR Therapeutics (Shanghai) Co., Ltd. (hereinafter referred to as “OTR”, or “we”) respects the privacy of visitors (“You” or “Users) to our website www.otr-tx.com (“Website”), and therefore we establish this Privacy Policy (this “Policy”) pursuant to the applicable laws and regulations of China on the protection of personal information. This Policy applies to this Website and the services you may use on this Website. Please read carefully and make sure that you fully understand this Policy. If you do not agree to this Policy, please do not use this Website.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Information Collection<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">When you interact with us through this Website, we may collect your personal information to perform and respond to your requests to us. Under this Policy, “Personal Information” means any information by which you can be identified, such as your name, birthday, e-mail address, postal address, telephone number, or education background and professional experience (such as to submit resume online). It is entirely your choice to provide us your Personal Information, and OTR only collects the information you provide to us. According to this Policy, you will be deemed to have agreed to our use of your Personal Information when you visit this Website and provide us with your Personal Information.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Information Use<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">We will use such Personal Information solely for the purposes of maintaining this website, assisting you to register to acquire relevant services you may need, and responding to your questions and requests for information. <p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">When we want to use Personal Information for other purposes not specified in this policy, we will seek your consent in advance. When we want to use the Personal Information collected for a specific purpose for other purposes, we will ask for your consent in advance.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Information Disclosures and Sharing<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Except as provided below, we will not share your Personal Information with third parties unless you have consented to the disclosure.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">sometimes we will ask some other companies or persons for service such as system technical support. To provide this kind of service, they may have access to your Personal Information but will not use the Personal Information for any other purpose.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">We may share Personal Information to respond to duly authorized subpoenas or other lawful information requests of governmental authorities, including to meet national security or law enforcement requirements, to provide Internet security, or where required by law.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">According to relevant laws and regulations, we may collect and use some necessary personal information without obtaining your authorized consent in the following situations：<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">(1)It is necessary for the conclusion and performance of any contract to which the individual is a party;<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">(2) It is necessary for the performance of statutory duties or obligations;<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">(3) It is necessary to respond to public health emergencies, or to protect the life, health and property safety of natural persons in emergency situations;<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">(4) Processing personal information that is publicly disclosed by individuals or others legally to a reasonable extent in accordance with the provisions of the Personal Information Protection Law;<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">(5) Other circumstances provided by laws and regulations.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Security Measures<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">In accordance with relevant national standards, we implement security precaution measures that satisfies industrial standards to protect your Personal Information. Nevertheless, you shall remain responsible to make sure that your computer is sufficiently secured and protected from leaking your Personal Information.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Third Party Links<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">This Policy applies only to this Website. This Website may contain links to other Websites ("Third-Party Websites") that are not operated or controlled by OTR. The policies and procedures described herein do not apply to Third-Party Websites. Links to this Website do not imply that we endorse or have reviewed Third-Party Websites. We encourage you to contact these sites directly to obtain their privacy policy.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Minor’s Privacy<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Our service does not address anyone under the age of fourteen (14). We do not knowingly collect personally identifiable information from minors under fourteen (14). In the case we discover that a minor under fourteen (14) has provided us with personal information, we immediately delete this from our servers. If you are a parent or guardian and you are aware that your child has provided us with personal information, please contact us so that we will be able to take necessary steps.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Miscellaneous<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">This Policy is made and effective on June 11, 2025, which is the latest version.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">OTR reserves the right to modify this Policy at any time by notifying Users, via the Website, of a new or updated Policy, and you can review the most up-to-date version on this Website.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Contact Us<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">If you have any questions about this Policy, please contact us at info@otr-tx.com.

Terms and Conditions

<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">This website www.otr-tx.com (“Website”) is developed and operated by OTR Therapeutics (Shanghai) Co., Ltd. (“OTR”). Any entity or individual is advised to read this Terms and Conditions carefully before access, browse or use this website. Do not access this Website if you do not consent to the terms herein. By your continued accessing, browsing, or using this Website, you will be deemed to have understood and fully agreed to be subject to this Terms and Conditions and abide by the laws and regulations applicable to this Terms and Conditions.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">You understand and agree that we may change this Terms and Conditions at any time without prior notice. Please review this Terms and Conditions periodically to make sure that you are aware of contents in the most up-to-date version. If you do not accept any revision to this Terms and Conditions, please stop visiting, browsing, and otherwise using the Website.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Your access to and use of this Website is also governed by the Privacy Policy of OTR, which is hereby incorporated by reference.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Prohibitions<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">When using this Website, you shall (a) not infringe lawful interests of OTR or other third parties, (b) not interfere with or attempt to interfere with, by any means whatsoever, normal operation of this Website, (c) not to attempt to decrypt, decompile, disassemble or reverse engineer any software contained on or constitutes this Website, (d) not to attempt discover the source code of this Website by any other means, (e)not to delete or change any published material by OTR or any other person or entity on this Website, or (f) not to include or link to any material or information provided on this Website within the web framework.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Content and Intellectual Property<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">All contents on this Website and their copyrights, including but not limited to data, texts, logos, graphics, audios, animations, records, videos, interface design, or page layout framework belong to OTR, unless otherwise indicated or be made known expressly that they belong to a third party. This website and all relevant contents are protected under the laws and regulations of China and applicable international laws and regulations on copyrights. Users are not allowed to use, reproduce or reuse such content for any purposes. OTR reserves all rights that we do not explicitly grant to users in this Terms.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">All trademarks, service marks, trade names, logos, and icons used and displayed on this Website are proprietary to OTR and its affiliates. Other company, product, and service names on this Website may be trademarks or service marks owned by third parties ("third-party trademarks", together with trademarks owned by OTR collectively referred to as "Trademark"). Nothing in this Website or this Terms and Conditions shall be construed as granting, by implication, estoppel or otherwise, any license or right to use any Trademarks displayed on this Website without the prior written consent of OTR or other relevant trademark owners. Trademarks may not be used to undermine the image, product, or service of OTR or any third party, or to damage the goodwill represented by the Trademark in any way (as judged by reasonable business rules).<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Disclaimers<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">TO THE FULL EXTENT PERMISSIBLE BY LAW, OFFICIALS, DIRECTORS, EMPLOYEES, AGENTS, SUPPLIERS OR LICENSORS OF EACH OF OTR AND ITS AFFILIATES (COLLECTIVELLY REFERRED TO AS “OTR PARTIES”) MAKE NO WARRANTIES, STATEMENTS OR REPRESENTATIONS, EXPRESS OR IMPLIED, ON ANY CONTENT ON THIS WEBSITE (INCLUDING BUT NOT LIMITED TO, PROMPTNESS, GENERALITY, PRECISION, RELIABILITY, COMPLETENESS OF SUCH CONTENT FOR A PARTICULAR PURPOSE, OR ACCURATENESS OR CREDIBILITY OF ANY INFORMATION GAINED FROM THIS WEBSITE). OTR MAKES NO COMMITMENT TO UPDATE ALL OR PART OF THE CONTENTS ON THIS WEBSITE IN A TIMELY MANNER. OTR RESERVES THE RIGHT TO CORRECT, MODIFY OR CEASE TO PUBLISH ALL OR ANY PART OF THE CONTENTS ON THIS WEBSITE WITHOUT NOTICE TO ANY PARTY AND SHALL NOT UNDERTAKE ANY LIABILITIES THEREOF. YOU ASSUME TOTAL RESPONSIBILITY FOR ALL THE RISKS ARISING FROM YOUR ACCEPTANCE OF ANY SUGGESTION, VIEW, STATEMENT, OR INFORMATION ON THIS WEBSITE, IN WHICH CASE OTR DISCLAIMS ANY AND ALL LIABILITY.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">FOR THE USE OF THIS WEBSITE OR ANY INFORMATION OBTAINED OR DOWNLOADED FROM THIS WEBSITE, YOU SHALL AGREE THAT YOU WILL, AT YOUR OWN RISK, DECIDE WHETHER TO USE THEM. OTR, ITS LICENSOR, SUPPLIERS OR ANY THIRD PARTY MENTIONED ON THIS WEBSITE SHALL NOT UNDERTAKE ANY LIABILITY FOR ANY LOSS RESULTING FROM THE USE OR UNAVAILABILITY OF THIS WEBSITE, OR ANY MALFUNCTION, COMPUTER VIRUS OR LOSS OF DATA OCCURRED IN OPERATION OR TRANSITION.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">According to relevant laws and regulations, we may collect and use some necessary personal information without obtaining your authorized consent in the following situations：<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Indemnification<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">You agree to hold, indemnify, and prevent OTR and OTR Parties from being liable for any claims, damages, costs, liability, or expense resulting from or allegedly resulting from your breach of this Terms and Conditions, including but not limited to direct losses such as administrative penalties or damages, and indirect losses such as loss of goodwill, settlement payments, reasonable attorney fees and accounting fees. In the event of such claims, damages, costs, liability, or expense, OTR will notify you. OTR has the right to exclusive defense and control of any matter for indemnification under this section. In this case, you agree to provide OTR with assistance as OTR may reasonably request in defending such matters.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Termination of use<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">OTR reserves the right, in its sole discretion, to limit, suspend, or terminate this Terms and Conditions and your rights to use all or any part of this Website or Content at any time and for any reason, without notice or liability. OTR reserves the right to change, suspend or terminate all or any part of this Website or Content at any time without notice or liability.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Medical Information<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Nothing on this Website shall be construed as providing any kind of medical advice or recommendation and shall not be relied on for any decision or action. Specific medical advice shall always be sought from a qualified medical practitioner.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Third Party Links<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">This Website contains links to third party websites. OTR shall not be deemed to have agreed to any of its contents by providing such links. Neither does OTR accept any responsibility for the availability or the contents of such websites or any liability or damage resulting from the use of such contents. Links to such websites are provided to users of this website merely for the sake of convenience. access such websites at their own risks.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Governing law<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Any dispute in connection with this Website or this Terms and Conditions shall be governed by laws of the People’s Republic of China, excluding the Hong Kong, Macau, and Taiwan.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Dispute Resolution<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">In the event of any dispute, controversy or claim arising out of or relating to these Terms of Use or your use of the Website, Content or Services, you shall attempt in the first instance to resolve such dispute through friendly consultations.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">In the event such dispute is not resolved through consultations within thirty (30) days after the date such consultations were first requested in writing, then you or we may submit the dispute for arbitration in Shanghai before the Shanghai International Economic and Trade Arbitration Commission(“SHIAC”) in accordance with SHIAC Arbitration Rules then in force. The arbitral award shall be final and binding, and shall be legally binding on both parties.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">Miscellaneous<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">If the clauses of this Terms shall be partially invalid or unenforceable for any reason, the remaining clauses shall remain in force and shall remain binding on the Parties. If a provision states that OTR has a particular right in a particular circumstance, this does not mean that that right is the only right OTR may exercise in that particular circumstance, or that that provision cancels, voids or invalidates any other provisions that deal with the same circumstance or subject-matter.<p style="padding: 0px; margin-top: 0px; margin-bottom: 10px; border: 0px; box-sizing: border-box; color: rgb(70, 70, 70); font-family: Figtree; font-size: 22px; line-height: 1.4; letter-spacing: -0.1px; white-space: normal; background-color: rgb(255, 255, 255);">The latest version of this Terms and Conditions is made and effective on June 11, 2025.